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Organometallic compounds contain direct bonds between carbon atoms and metal atoms/ions and play roles as homogeneous catalysts and stoichiometric reagents in reactions; available in various chemical compositions, quantities, purities, and reagent grades.
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(S,R,S)-AHPC-C6-PEG3-C4-Cl is a VHL E3 ligase ligand-linker conjugate used as a building block for PROTAC design and targeted protein degradation research. It combines a stereodefined AHPC VHL ligand with a mixed C6-PEG3-C4 linker and has been used in cell-based assays to induce degradation of HaloTag fusion proteins.
Used as a VHL E3 ligase ligand building block for PROTAC synthesis.
Soluble in DMSO at 100 mg/mL (may require ultrasonication).
Suitable for in vivo formulations at ≥2.5 mg/mL in recommended cosolvent systems.
Stable in pure form when stored at -20°C for extended periods.
Molecular weight 751.42 g/mol and molecular formula C38H59ClN4O7S.
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(S,R,S)-AHPC-PEG3-NH2 hydrochloride is a VHL E3 ligase ligand-linker conjugate supplied as the hydrochloride salt for use in PROTAC development and related chemical biology research. It is a PEG3-linked derivative of the AHPC VHL ligand and is provided in multiple packaged sizes for synthesis and assay workflows.
VHL E3 ligase ligand-linker conjugate suitable for PROTAC design.
Provided as the hydrochloride salt for improved solubility and handling.
Available in multiple sizes, including 2 G.
Molecular formula C30H46ClN5O7S; molecular weight 656.23.
Purity ≥95% by supplier specification.
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IDE 1 (CAS 1160927-48-9) is a small-molecule compound designed to promote differentiation of stem cells toward the definitive endoderm lineage by activating receptors involved in the TGF- signaling pathway IDE 1 exerts its biological activity primarily through activation of the TGF- signaling pathway In in vitro studies IDE 1 induces definitive endoderm specification from pluripotent stem cells Based on these pharmacological properties IDE 1 holds research potential in in vitro differentiation protocols to generate endoderm-derived cells such as hepatocytes and pancreatic cells and in studies investigating early embryonic lineage commitment and regenerative medicine
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Ms-PEG5-t-butyl ester is a PEG-based linker featuring a t-butyl-protected carboxyl group, designed for use in the chemical synthesis of PROTAC molecules. It provides a hydrophilic spacer to connect ligands while masking the carboxylate during multi-step syntheses.
Provides a hydrophilic polyethylene glycol spacer to improve solubility.
Contains a t-butyl-protected carboxyl group for orthogonal protection during synthesis.
Compatible with standard coupling and deprotection chemistries used in medicinal chemistry.
Facilitates assembly of bifunctional degraders by spacing ligands and reducing steric hindrance.
Available in small-scale quantities suitable for research and discovery workflows.
Reported high purity suitable for synthetic applications; verify with certificate of analysis.
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Azido-PEG3-SS-PEG3-azide is a symmetric, cleavable polyethylene glycol (PEG)-based bifunctional linker bearing terminal azide groups and a central disulfide bond. It is designed for bioconjugation and PROTAC synthesis, enabling both copper-catalyzed azide-alkyne cycloaddition (CuAAC) and strain-promoted azide-alkyne cycloaddition (SPAAC), while allowing reductive cleavage for controlled release.
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Trimethylammonium chloride (Standard) is the analytical standard of Trimethylammonium chloride This product is intended for research and analytical applications Trimethylammonium chlorideIt is an endogenous metabolite that inhibits deacetylation Trimethylammonium chlorideIs a non-competitive inhibitor of acetylcholinesterase[1][2]
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ATN-161 trifluoroacetate salt is a peptide integrin α5β1 antagonist supplied as the trifluoroacetate (TFA) salt for research use. It has been reported to inhibit angiogenesis and reduce growth of liver metastases in murine models. The product is supplied as a white to off-white solid with high purity and accompanying analytical documentation.
Peptide integrin α5β1 antagonist, suitable for preclinical research.
Provided as the trifluoroacetate salt for improved stability and handling.
High purity (approximately 99.0%), with COA and analytical data available.
Solid form, white to off-white, convenient for storage and formulation.
Storage recommendations: refrigerated sealed storage; long-term in solvent at -80°C.
Available in small-milligram quantities for laboratory experiments.
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Trimethylammonium chloride (Standard) is the analytical standard of Trimethylammonium chloride This product is intended for research and analytical applications Trimethylammonium chlorideIt is an endogenous metabolite that inhibits deacetylation Trimethylammonium chlorideIs a non-competitive inhibitor of acetylcholinesterase[1][2]
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